| Methods |
Randomised controlled trial. The doctors giving the fluid were blinded to the solution but blinding of outcome assessors not mentioned. Loss to follow‐up not reported |
| Participants |
45 consecutive trauma patients transferred to the surgical ICU. Inclusion criteria: injury severity score of > 15 points
All patients were haemodynamically stable before being admitted to the study |
| Interventions |
1) 10% HES (n = 15)
2) 20% HA (n = 15)
3) Unspecified volume therapy regimen (n = 15)
The allocated solution was given to maintain CVP and or PAWP between 12 mmHg and 18 mmHg |
| Outcomes |
Death
Haemodynamic variables
Circulating adhesion molecules |
| Notes |
Deaths were reported within the study period and later (left ITU). Information on allocation concealment was obtained on contact with the study author |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
Adequate. Sequentially numbered sealed opaque envelopes |
