Gondos 2010.
Methods | Randomised controlled study | |
Participants | 200 postoperative haemodynamically stable hypovolaemic patients needing intensive care treatment because of general health status. Exclusion criteria: aged < 18 years, active bleeding or shock, severe pulmonary oedema, known uraemia, anaphylactic reaction to colloid fluids, and life expectancy less than 24 hours | |
Interventions | 1) 4% Gelatin (n = 50) 2) 6% HES (n = 50) 2) 5% HA (n = 50) A fourth group were given LR (n = 50) |
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Outcomes | Death Haemodynamic variables Length of ICU stay |
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Notes | Final follow‐up 10th postoperative day. Additional information on allocation obtained from study author | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment (selection bias) | Low risk | Adequate ‐ 'randomised by blinded envelope technique ‐ each centre had got 20 closed, opaque envelopes which were sequentially numbered' |