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. 2012 Jul 11;2012(7):CD001319. doi: 10.1002/14651858.CD001319.pub5

Kirklin 1984.

Methods Randomised controlled trial. No information given on method of randomisation 
 Blinding not mentioned 
 No loss to follow‐up
Participants 30 patients undergoing coronary artery operations. Patients were excluded if they had undergone previous cardiac operations, if they had severe coagulopathies, anaemia, or CRF
Interventions 1) 6% HES (n = 15) 
 2) 5% Albumin (n = 15) 
 Both fluids infused over 24 hours to maintain left arterial pressure between 6 mmHg and 12 mmHg and cardiac index > 2.0 L/minute/m2
Outcomes Death 
 Haemodynamic and coagulation variables 
 Adverse reactions
Notes Follow‐up until discharge from ICU 
 34 patients were originally included in the trial but data from 4 of them was not included in the final analysis
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk Unclear. No information given on allocation concealment