| Methods |
Randomised controlled trial
Blinding not mentioned
Loss to follow‐up not mentioned |
| Participants |
18 patients undergoing modified Whipple's operation (hemipancreato‐duodenectomy). Patients were eligible for the study if there was an absence of major organ dysfunction and serum protein, sodium, glucose, blood urea nitrogen, haematocrit, aPTT and PT times, and platelet times were within normal limits. Specific exclusion criteria included compensated myocardial insufficiency, chronic hypertension, chronic obstructive airways disease, and insulin‐dependent diabetes mellitus |
| Interventions |
1) 10% HES (n = 6)
2) 20% HA (n = 6)
A third group were given RL (n = 6)
All given as a volume replacement solution, which was given to maintain CVP at the preoperative level |
| Outcomes |
Death (data on death was obtained on contact with the study author)
Haemodynamic variables
Clotting variables |
| Notes |
Follow‐up unspecified
Study was intraoperative |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
Unclear. No information on allocation |
