| Methods |
Randomised controlled trial
No loss to follow‐up
Blinding not mentioned |
| Participants |
20 patients with severe sepsis and systemic hypoperfusion. Patients were excluded from the study if they were < 21 years of age, pregnant, considered to be terminal, or they manifested spontaneous bleeding |
| Interventions |
1) 5% Albumin (n = 10)
2) 10% HES (pentastarch) (n = 10)
Each group received 250 mL of the treatment fluid every 15 minutes until either the WP was 15 mmHg or less or a maximum volume of 2000 mL of study colloid was infused |
| Outcomes |
Death
Haemodynamic variables
Clotting variables
Allergic reactions |
| Notes |
Follow‐up unspecified |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
Unclear. No information on allocation |
