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. 2019 Sep 8;40(2):683–708. doi: 10.1002/med.21633

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© 2019 The Authors. Medicinal Research Reviews Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Equilibrium displacement of [³H]ZM‐241,385 (antagonist) and [³H]NECA (agonist) binding to A_2AAR by allosteric modulators. A, NaCl, B, amiloride, and C, HMA. Reproduced with permission from Gutiérrez‐de Terán et al.27 HMA, 5‐(N,N‐hexamethylene)amiloride; NECA, 5'‐(N‐ethylcarboxamido)adenosine