Table 3.
Longitudinal follow‐up associations (per standard deviation change in transformed biomarker)
| Adjusted associations | ||||
|---|---|---|---|---|
| MDS‐UPDRS III | Intercept | Slope (per year) | Intercept q value | Slope q value |
| ApoA1 | −0.90 (−2.06 to 0.25); 0.12 | −0.06 (−0.40 to 0.29); 0.74 | 0.17 | 0.91 |
| CRP | −0.35 (−1.39 to 0.69); 0.51 | 0.26 (−0.05 to 0.57); 0.09 | 0.51 | 0.19 |
| Uric acida | −0.96 (−2.02 to 0.10); 0.08 | 0.36 (0.04 to 0.68); 0.03 | 0.17 | 0.11 |
| Vitamin D | −0.82 (−1.87 to 0.24); 0.13 | 0.02 (−0.29 to 0.33); 0.91 | 0.17 | 0.91 |
| MoCA | Adjusted associations | |||
| Intercept | Slope (per year) | Intercept q value | Slope q value | |
| ApoA1 | 0.29 (−0.02 to 0.60); 0.07 | 0.00 (−0.08 to 0.08); 0.99 | 0.24 | 0.99 |
| CRP | −0.19 (−0.48 to 0.09); 0.18 | −0.02 (−0.10 to 0.05); 0.50 | 0.24 | 0.67 |
| Uric acida | 0.21 (−0.08 to 0.50); 0.16 | −0.03 (−0.10 to 0.05); 0.48 | 0.24 | 0.67 |
| Vitamin D | 0.16 (−0.13 to 0.45); 0.27 | 0.03 (−0.05 to 0.10); 0.48 | 0.27 | 0.67 |
| MDS‐UPDRS II | Adjusted associations | |||
| Intercept | Slope (per year) | Intercept q value | Slope q value | |
| ApoA1 | −0.93 (−1.50 to −0.35); 0.002 | −0.07 (−0.21 to 0.07); 0.34 | 0.004 | 0.45 |
| CRP | 0.81 (0.29 to 1.34); 0.002 | 0.11 (−0.03 to 0.24); 0.12 | 0.004 | 0.29 |
| Uric acida | 0.04 (−0.49 to 0.57); 0.88 | 0.04 (−0.09 to 0.18); 0.53 | 0.88 | 0.53 |
| Vitamin D | −0.75 (−1.28 to −0.22); 0.005 | −0.10 (−0.23 to 0.03); 0.14 | 0.007 | 0.29 |
| MDS‐UPDRS I | Adjusted Associations | |||
| Intercept | Slope (per year) | Intercept q value | Slope q value | |
| ApoA1 | −0.82 (−1.31 to −0.33); <0.001 | −0.02 (−0.13 to 0.09); 0.76 | 0.004 | 0.76 |
| CRP | 0.45 (0.01 to 0.90); 0.047 | 0.06 (−0.04 to 0.17); 0.22 | 0.06 | 0.61 |
| Uric acida | 0.53 (0.08 to 0.99); 0.02 | −0.05 (−0.16 to 0.05); 0.31 | 0.04 | 0.61 |
| Vitamin D | −0.41 (−0.86 to 0.05); 0.08 | −0.03 (−0.13 to 0.07); 0.56 | 0.08 | 0.75 |
MDS‐UPDRS, Movement Disorder Society Unified Parkinson's Disease Rating Scale; MoCA, Montreal Cognitive Assessment; ApoA1, apolipoprotein A1; CRP, C‐reactive protein.
Data (except where stated) are estimate (95% confidence interval); P value. Models are adjusted for age at diagnosis and sex.
a
Uric acid was standardized by sex so the adjusted associations are not adjusted with a sex term in the model.