Table 4.
Pattern mixture model (adjusted for withdrawal) longitudinal follow‐up associations (per standard deviation change in transformed biomarker)
| Adjusted associations | ||||
|---|---|---|---|---|
| MDS‐UPDRS III | Intercept | Slope (per year) | Intercept q value | Slope q value |
| ApoA1 | −0.93 (−2.02 to 0.16); 0.10 | 0.04 (−0.30 to 0.38); 0.82 | 0.36 | 0.90 |
| CRP | −0.40 (−1.40 to 0.60); 0.43 | 0.26 (−0.07 to 0.58); 0.12 | 0.43 | 0.24 |
| Uric acida | −0.70 (−1.82 to 0.41); 0.22 | 0.29 (−0.05 to 0.64); 0.10 | 0.36 | 0.24 |
| Vitamin D | −0.65 (−1.79 to 0.50); 0.27 | −0.02 (−0.38 to 0.33); 0.90 | 0.36 | 0.90 |
| MoCA | Adjusted Associations | |||
| Intercept | Slope (per year) | Intercept q value | Slope q value | |
| ApoA1 | 0.29 (−0.04 to 0.62); 0.08 | −0.02 (−0.11 to 0.07); 0.64 | 0.23 | 0.72 |
| CRP | −0.17 (−0.46 to 0.12); 0.24 | −0.03 (−0.12 to 0.06); 0.57 | 0.28 | 0.72 |
| Uric acida | 0.25 (−0.06 to 0.55); 0.12 | −0.05 (−0.14 to 0.05); 0.32 | 0.23 | 0.72 |
| Vitamin D | 0.16 (−0.12 to 0.44); 0.28 | 0.02 (−0.07 to 0.10); 0.72 | 0.28 | 0.72 |
| MDS‐UPDRS II | Adjusted associations | |||
| Intercept | Slope (per year) | Intercept q value | Slope q value | |
| ApoA1 | −0.73 (−1.33 to −0.13); 0.02 | −0.16 (−0.35 to 0.02); 0.08 | 0.02 | 0.32 |
| CRP | 0.76 (0.18 to 1.34); 0.01 | 0.11 (−0.05 to 0.27); 0.17 | 0.02 | 0.33 |
| Uric acida | 0.07 (−0.52 to 0.66); 0.82 | 0.06 (−0.11 to 0.24); 0.48 | 0.82 | 0.48 |
| Vitamin D | −0.74 (−1.31 to −0.17); 0.01 | −0.06 (−0.23 to 0.11); 0.48 | 0.02 | 0.48 |
| MDS‐UPDRS I | Adjusted associations | |||
| Intercept | Slope (per year) | Intercept q value | Slope q value | |
| ApoA1 | −0.65 (−1.20 to −0.11); 0.02 | −0.10 (−0.26 to 0.07); 0.25 | 0.08 | 0.49 |
| CRP | 0.40 (−0.10 to 0.90); 0.12 | 0.08 (−0.06 to 0.23); 0.24 | 0.12 | 0.49 |
| Uric acida | 0.50 (−0.01 to 1.00); 0.06 | −0.03 (−0.16 to 0.10); 0.63 | 0.11 | 0.79 |
| Vitamin D | −0.44 (−0.99 to 0.11); 0.12 | 0.02 (−0.11 to 0.14); 0.79 | 0.12 | 0.79 |
MDS‐UPDRS, Movement Disorder Society Unified Parkinson's Disease Rating Scale; MoCA, Montreal Cognitive Assessment; ApoA1, apolipoprotein A1; CRP, C‐reactive protein.
Data (except where stated) are estimate (95% confidence interval); P value. Models are adjusted for age at diagnosis and sex.
a
Uric acid was standardized by sex but the adjusted associations are still adjusted with a sex term in the model because the interaction between sex and withdrawal has residual confounding with the standardized uric acid.