Table 2.

Notch signaling in respiratory diseases

	Related Notch genes	Functions of Notch
PAH
Pulmonary artery hypertension	Notch3 overexpression	Increased proliferation of vascular smooth muscle cells
COPD
Chronic obstructive pulmonary disease	Enhanced NICD1 in mucosal hyperplasic regions	Notch signaling promotes mucosal hyperplasic
	Decreased Notch signaling as a whole	Notch down regulation induces emphysema via endothelial cell apoptosis
IPF
Interstitial pulmonary fibrosis	Enhanced NICD1 in highly fibrotic alveolar regions	Profibrotic via inducing endothelial‐mesenchymal transition (EMT)
Lung cancer
Non‐small cell lung cancer (NSCLC)	Notch3 over expression in NSCLC	Highly complex and context‐dependent functions
Small cell lung cancer (SCLC)	Decreased Notch signaling via Dlk1/DII3 in SCLC	Tumor promotor in NSCLC
		Tumor suppressor in SCLC