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. 2019 Nov 24;113(1):4–21. doi: 10.1111/mmi.14409

Figure 1.

Figure 1

Structure of the EspG5‐PPE41‐PE25 complex (4KXR). The EspG chaperone (Gold) binds to the EspG‐binding domain of the PPE protein (Light blue), thereby conferring TypeVII secretion system specificity (Daleke et al., 2012b; Korotkova et al., 2014; Phan et al., 2017). The rest of the PPE‐protein interacts with its PE partner (Teal) via hydrophobic interactions. The conserved WxG residues of the PPE (Pink) and YxxxD/E of the PE (Red) are closely associated and may form a composite TypeVII secretion signal. The C‐terminus of the PPE (Green) extends toward the C‐terminus of the PE (Red), suggesting that PE/PPE protein pairs with C‐terminal extensions may have further PE/PPE interactions between those specific domains.