Figure 5.

RD5 and ppe38 polymorphisms in M. africanum and the animal‐adapted species of the M. tuberculosis complex. The phylogeny is adapted from Brites et al. with permission of the author (Brites et al., 2018). Independent RD5 deletions, with unique remaining flanking sequences, are depicted in the phylogenetic tree. The organization of the ppe38 locus in M. africanum L5, L6 and M. microti and M. pinnipedii is indicated with arrows, similar as in Fig. 4. Only one out of 18 M. africanum L5 isolates was found to have an RD5‐like deletion (Ates et al., 2018a). In a study by Brodin et al. three M. microti isolates from humans had an intact RD5‐locus, while four strains isolated from voles had RD5‐deletions (Brodin et al., 2002).