Figure 3.

Skin Pathophysiology associated with deregulation of homeostatic Cav1 levels. It is the fine balance of Cav1 that is key to physiologic skin structure and function, as the slight imbalance in one direction or another affects localization and activation of various key signalling molecules and can tip the scale towards one of numerous skin pathologies. On one side, upregulation of Cav1 has been implicated in skin ageing, development of non‐healing chronic wounds and, whereas downregulation has been associated with squamous cell carcinoma, basal cell carcinoma, cutaneous fibroses, psoriasis and alopecia