Table 2.
Sensitivity and PPV of varying algorithm with different levels of overlap with eCRF‐identified AECOPD episodes compared with AECOPD episodes in primary and secondary care EHR data and primary care only EHR data
| Distance between AECOPD Episodes, d | AECOPD Episodes Concurrent with eCRF Episodes, n | Sensitivity, % | 95% CI | PPV, % | 95% CI | |
|---|---|---|---|---|---|---|
| Primary and secondary care EHR data | 0a | 2801 | 63.6 | 62.2‐65.0 | 71.1 | 69.7‐72.5 |
| 3 | 2851 | 64.8 | 63.3‐66.2 | 72.1 | 70.7‐73.5 | |
| 7 | 2918 | 66.3 | 64.9‐67.7 | 73.1 | 71.7‐74.4 | |
| 15 | 3042 | 69.1 | 67.7‐70.5 | 73.6 | 72.2‐74.9 | |
| 30 | 3245 | 73.7 | 72.4‐75.0 | 67.6 | 66.3‐68.9 | |
| Primary care only EHR data | 0a | 2690 | 61.1 | 59.6‐62.5 | 72.4 | 70.9‐73.8 |
| 3 | 2746 | 62.4 | 60.9‐63.8 | 73.6 | 72.1‐75.0 | |
| 7 | 2807 | 63.8 | 62.3‐65.2 | 74.5 | 73.1‐75.9 | |
| 15 | 2932 | 66.6 | 65.2‐68.0 | 75.1 | 73.8‐76.5 | |
| 30 | 3138 | 71.3 | 69.9‐72.6 | 69.1 | 67.7‐70.4 |
Abbreviations: AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CI, confidence interval; eCRF, electronic case report form; EHR, electronic health record; PPV, positive predictive value.
a
Zero days distance between episodes is equivalent to 1‐day overlap.