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Reduced proliferation rates and increased apoptosis in cell overexpressing Nek1-T141A mutant after treatment with doxorubicin. (a, b) Proliferation rates were determined for Hek293 and LNCaP cells during a week recovery from 12 h exposure to doxorubicin (200 nM). Results are expressed in relation to untreated “parental” cells. (c–f). Cells overexpressing Nek1-T141A show elevated activated Caspase 3 when treated with low doses [200 (+) or 400 (++) nM] doxorubicin.
