Figure 7.

hucMSC-exo-carried miR-19a protects cardiomyocytes by activating AKT and inhibiting JNK3/caspase-3 activation. Protein levels of AKT, JNK 3 and caspase-3 and phosphorylation levels of p-AKT and p-JNK3 were detected by western blot analysis. *p < 0.05, **p < 0.01. All experiments were repeated for three times. Data in panels i, ii, iv were analyzed by one-way ANOVA and data in panel iii were analyzed by two-way ANOVA, and checked by Tukey’s multiple comparisons test for pairwise comparison after ANOVA. hucMSC-exo, human umbilical cord mesenchymal stem cells-exosome; miR-19a, microRNA-19a; AKT, protein kinase B; JNK, Jun N-terminal kinase; ANOVA, analysis of variance.