Table 2. Summary of results of multivariate linear regression and multiple comparison: OSA is the independent risk factor of DNA methylation levels over CpG site #1, #2, #3, #18, #25 and #28 of the TLR2 promoter region, CpG site #1 and #3 of TLR6 gene body, and protein expression of TLR6.
(The complete data was presented at S6 Table).
| Multivariate linear regression | Multiple comparisons | |||||||
|---|---|---|---|---|---|---|---|---|
| △F | p | △R2 | β | t | pr2 | q | ||
| TLR2 promoter region | CpG#1 | 4.546 | .037 | .051 | .327 | 2.132 | .071 | .153 |
| CpG#2 | 5.202 | .026 | .055 | .339 | 2.281 | .081 | .123 | |
| CpG#3 | 5.293 | .025 | .053 | .335 | 2.301 | .082 | .123 | |
| CpG#18 | 4.333 | .042 | .056 | -.342 | -2.082 | .069 | .154 | |
| CpG#25 | 6.221 | .015 | .072 | .389 | 2.494 | .095 | .123 | |
| CpG#28 | 5.856 | .019 | .070 | .383 | 2.420 | .090 | .123 | |
| TLR6 gene body | CpG#1 | 20.736 | < .001 | .192 | .635 | 4.554 | .260 | < .001 |
| CpG#3 | 9.421 | .003 | .120 | .502 | 3.069 | .138 | .033 | |
| Protein expression | TLR6 | 97.805 | < .001 | .325 | .825 | 9.890 | .645 | < .001 |