Figure 2: Deletion of IDOL from peripheral tissues does not protect against diet-induced metabolic dysfunction.

(a-e) Growth curves showing the mean mass +/− SEM for male mice from each conditional knockout mouse strain tested. (f-j) Adiposity reported as body fat percentage +/− SEM measured by MRI or DEXA after 15 weeks consuming the indicated test diet. (a, f) Liver-specific IDOL KO mice (n=12 Idol(AZ)^f/f, n=12 Idol(AZ)^f/f Cre^Alb) fed a high-fat, high-cholesterol (HFHC) diet for 15 weeks beginning when mice were eight weeks old. Adiposity measured by DEXA scan. (b,g) Adipose-specific IDOL KO mice (n=13 Idol^f/f, n=17 Idol^f/fCre^AdipoQ) fed a western diet for 15 weeks starting when the mice were six weeks old. Adiposity measured by MRI. (c,h) Endothelium-specific IDOL KO mice (n=21 Idol^f/f, n=22 Idol^f/f Cre^Cdh5) fed a western diet for 15 weeks starting when the mice were six weeks old. Adiposity measured by MRI. (d,i) Intestine-specific IDOL KO mice (n=13 Idol^f/f, n=19 Idol^f/f Cre^Vil) fed a western diet for 15 weeks starting when the mice were six weeks old. Adiposity measured by MRI. (e,j) Muscle-specific IDOL KO mice (n=11 Idol^f/f, n=18 Idol^f/f Cre^Mck) fed a western diet for 15 weeks starting when the mice were six weeks old. Adiposity measured by MRI. There were no statistically significant differences between groups in any panel of this figure. The precise n-number, p-value, and details of the statistical testing are listed in the source data file.