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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Nat Metab. 2019 Oct 28;1(11):1089–1100. doi: 10.1038/s42255-019-0127-7

Figure 3: IDOL regulates systemic energy balance through the VLDL receptor.

Figure 3:

(a) Growth curves showing the mean mass and the standard error of the mean (SEM) for male mice placed on a high fat high cholesterol (HFHC) diet from 6–8 weeks of age; n=11 wild type (WT), n=18 Idol−/− (KO), n=18 Idol−/−Ldlr−/− (LDLR DKO) mice. (b) Growth curves showing the mean mass +/− SEM for male wild-type (WT) n=20, Idol−/− (IDOL KO) n=15, Vldlr−/− (VLDLR KO) n=12, and Idol−/−Vldlr−/− (VLDLR DKO) n=7 mice fed a HFHC diet from 6–8 weeks of age. (c) Intraperitoneal glucose tolerance test (1 g/kg) administered after six weeks on the HFHC diet. The values shown are the mean blood glucose levels +/− SEM. (d) Intraperitoneal insulin tolerance test (1U/kg) administered after ten weeks on the HFHC diet. The values shown are the mean blood glucose levels +/− SEM. (e) Adiposity reported as body fat percentage +/− SEM measured by MRI for the mice reported in panel (a) at baseline and after 8 weeks on the HFHC diet. (f) Adiposity reported as body fat percentage +/− SEM measured by MRI for the mice reported in panel (b) at baseline and after 8 weeks on the HFHC diet. (g) The area under the curve (AUC) was calculated for the glucose tolerance test for each mouse and the mean values +/− SEM and individual values are plotted. (h) The area under the curve (AUC) was calculated for the insulin tolerance test for each mouse and the mean values +/− SEM and individual values are plotted. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. The precise n-number, p-value, and details of the statistical testing are provided in the source data file.