Skip to main content
. Author manuscript; available in PMC: 2020 Sep 18.
Published in final edited form as: ACS Chem Neurosci. 2019 Aug 19;10(9):4018–4030. doi: 10.1021/acschemneuro.9b00271

Figure 2.

Figure 2.

(A) Inhibitory effects of TPPU on the activities of 40 kinases relevant to AD. Kinases were assayed in the presence of 1 μM TPPU or control (0.2% PEG400 vehicle). Data were the mean of duplicate of each of six independent experiments with ± SEM (n = 6). The data were analyzed by one-way ANOVA with Tukey’s multiple comparison test. **p < 0.01, ***p < 0.001, ****p < 0.0001 relative to the control. (B) TPPU inhibited p38β kinase activity with an IC50 value of 0.27 μM. (C) TPPU inhibited p38γ kinase activity with an IC50 value of 0.89 μM.