Figure 1.
Epigenome-wide association study results for placental copper status.
Volcano plots display the p-value and effect estimate (log fold change) for the a. RICHS, b. the NHBCS cohort-level associations, as well as for c. the meta-analysis. d. The Manhattan plot of meta-analysis results indicates -log10(p-value) for individual CpG associations with placental copper status, as well as locations on the chromosomes (indicated on x-axis). Red vertical lines indicate differentially methylated regions found by CombP. Blue dots represent CpGs within the DMR.