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. 2020 Feb 12;9(1):1726168. doi: 10.1080/2162402X.2020.1726168

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — B cells were required for maximal antitumor efficacy of oncolytic virotherapy. (A, B) Evaluation of the antitumor effects of OVH therapy was carried out in wild-type C57BL/6 (B6) and J_HT mice. Mice were s.c. inoculated with Hepa1-6 cells in both flanks and treated 10 days later and every 3 days thereafter until the total two dosages were finished, with OVH or vehicle. Black arrow indicates virus injection. Tumor growth of virus-injected (A) and distant (B) Hepa1-6 tumors. (C) Tumor growth of distant Hepa1-6 tumors in OVH-treated B6 and J_HT mice. (D-G) The tumors in both flanks from each group were dissected and weighed at experiment termination (F, G). Tumor weight of virus-injected tumors (D) and distant tumors (E). All values are presented as the mean ± SEM. *P < .05, ***P < .001, ****P < .0001, ns, not significant by repeated measure ANOVA (A, B) or by one-way ANOVA (D, E).