Table 2.
Univariate and Multivariate Analysis with Disease Relapse after curative surgery.
| Univariate |
Multivariate |
|||||
|---|---|---|---|---|---|---|
| Variable | Total (%) | HR | P-value | HR | 95% CI | P-value |
| Age, years | 1.51 | 0.73 | ||||
| <65 | 3 (15.0) | |||||
| ≥65 | 8 (21.1) | |||||
| Tumor depth | 25.7 | 0.0001 | 42.1 | 2.95-600 | 0.0058 | |
| T2, T3 | 4 (8.3) | |||||
| T4 | 7 (70.0) | |||||
| Lymph node metastasis | 1.66 | 0.73 | ||||
| N0 | 3 (14.3) | |||||
| N1, N2 | 8 (21.6) | |||||
| Stage | 1.66 | 0.73 | ||||
| II | 3 (14.3) | |||||
| III | 8 (21.6) | |||||
| Sidedness | 1.41 | 0.74 | ||||
| Right side | 4 (16.0) | |||||
| Left side | 7 (21.2) | |||||
| Mismatch repair (MMR) | 0.84 | 1.00 | 0.12 | 0.002–10.2 | 0.35 | |
| MMR-proficient | 10 (19.2) | |||||
| MMR-deficient | 1 (16.7) | |||||
| Adjuvant therapy | 0.81 | 1.00 | ||||
| Yes | 5 (20.8) | |||||
| No | 6 (17.7) | |||||
| Immunoscore | 0.29 | 0.43 | 0.11 | 0.002–7.38 | 0.35 | |
| Low | 10 (22.2) | |||||
| Intermediate/High | 1 (7.7) | |||||
| No. of TLS per 100 mm2 of tumor region | 1.30 | 1.00 | ||||
| <4.5 | 4 (16.7) | |||||
| ≥4.5 | 7 (20.6) | |||||
| Proportion of helper T cell | 12.0 | 0.0012 | 9.89 | 1.28–76.3 | 0.028 | |
| <32.2% | 4 (8.9) | |||||
| ≥32.2% | 7 (53.9) | |||||
| Proportion of Macrophage | 8.72 | 0.0061 | 4.21 | 0.56–31.8 | 0.16 | |
| <3.40% | 2 (6.06) | |||||
| ≥3.40% | 9 (36.0) | |||||
TLS; tertiary lymphoid structure, HR; hazard ratio, CI; confidence interval