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. 2019 Sep 17;15(3):307–322. doi: 10.1080/15592294.2019.1666652

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Gene expression profile of 25 genes after single or combinatorial treatment with VC and ML309 for 48 h in IDH1^+/+ and IDH1^R132H/+ cells.

Heat map of relative mRNA-levels of the differential expressed genes in (a) IDH1^+/+ and (b) IDH1^R132H/+ cells after treatment with VC (1 mM), ML309 (10 µM) and combinatorial treatment. (relative to the HMBS housekeeper gene, using the 2^ΔΔCT method)