TABLE 4.
Adjusted ORs for ferritin levels of less than 12 ng/mL in reduced models, stratified by race/ethnicity*
| Ferritin <12 ng/mL |
||||
|---|---|---|---|---|
| Risk factor | African American | Asian | Hispanic | NHW |
| % <12 ng/mL in reference group* | 0.9 | 3.5 | 3.0 | 6.0 |
| Sex | p < 0.0001 | p = 0.0001 | p < 0.05 | p < 0.0001 |
| Female | 16.3 (4.7-57.2) | 6.6 (2.5-17.0) | 3.2 (1.0-10.4) | 2.7 (1.9-3.6) |
| Male | Ref | Ref | Ref | Ref |
| Age (years), female/male | p = 0.0220/p = 0.0102 | p = 0.0003/p = 0.02 | p = 0.4029/p = 0.7374 | p < 0.0001/p = 0.0773 |
| 18-19 | 1.9 (0.99-3.7)/8.8 (2.1-36.4) | NA†/NA† | 5.6 (2.8-11.3)/2.0 (0.5-7.9) | 2.7 (1.8-4.1)/1.5 (0.72-3.15) |
| 20-29 | 1.6 (0.93-2.8)/2.1 (0.49-8.8) | 1.5† (0.81-2.6)/0.71† (0.24-2.0) | 2.6 (1.4-4.9)/1.8 (0.53-5.9) | 1.7 (1.3-2.3)/1.1 (0.77-1.64) |
| 30-39 | 1.1 (0.6-1.9)/1.5 (0.29-7.8) | 1.4 (0.72-2.6)/2.6 (1.1-6.5) | 2.4 (1.3-4.7)/1.2 (0.37-4.9) | 0.98 (0.73-1.3)/1.1 (0.79-1.6) |
| 40-49 | Ref | Ref | Ref | Ref |
| 50-59 | 0.27 (0.13-0.55)/2.0 (0.53-7.9) | 0.33 (0.14-0.83)/1.3 (0.41-4.0) | 0.6 (0.26-1.4)/1.12 (0.28-4.5) | 0.64 (0.51-0.82)/0.87 (0.66-1.2) |
| 60+ | 0.27 (0.13-0.56)/1.1 (0.23-5.2) | 0.07 (0.01-0.53)/2.6 (0.79-8.7) | 0.66 (0.19-2.3)/0.47 (0.05-4.7) | 0.44 (0.35-0.57)/0.79 (0.61-1.04) |
| Weight | p = 0.002 | p = 0.1046 | p < 0.0001 | p < 0.0001 |
| Per pound | 0.99 (0.98-1.0) | 0.99 (0.98-1.0) | 0.99 (0.985-0.995) | 0.994 (0.992-0.996) |
| Donation frequency | p < 0.0001 | p < 0.0001 | p < 0.0001 | p < 0.0001 |
| 0 donations past 2 years | Ref | Ref | Ref | Ref |
| 1-2 | 1.8 (1.2-2.7) | 2.7 (1.8-4.1) | 2.1 (1.4-3.2) | 1.7 (1.3-2.1) |
| 3-4 | 4.7 (2.8-8.1) | 3.4 (1.0-5.6) | 5.3 (3.1-9.1) | 3.5 (2.7-4.4) |
| 5-6 | 9.9 (5.1-19.2) | 3.5 (1.6-7.5) | 11.3 (5.2-24.7) | 6.4 (4.9-8.2) |
| 7+ | 13.1 (6.3-27.5) | 7.8 (3.9-15.6) | 10.4 (4.6-23.5) | 9.5 (7.5-11.9) |
| Iron Supplement | p = 0.34 | p = 0.053 | p = 0.64 | p < 0.0001 |
| Daily | 0.84 (0.55-1.3) | 0.54 (0.32-0.92) | 0.8 (0.48-1.34) | 0.57 (0.50-0.66) |
| Less than daily | 0.69 (0.41-1.2) | 0.74 (0.46-1.2) | 1.1 (0.65-1.8) | 0.84 (0.71-0.99) |
| None | Ref | Ref | Ref | Ref |
| Blood center | p = 0.90 | p < 0.0001 | p = 0.54 | p = 0.001 |
| ARC | Ref | Ref | Ref | Ref |
| BCW | 0.89 (0.57-1.4) | 1.3 (0.64-2.76) | 1.2 (0.58-2.7) | 0.94 (0.80-1.09) |
| BSRI | 1.0 (0.6-1.9) | 0.44 (0.3-0.65) | 0.84 (0.58-1.2) | 0.66 (0.54-0.82) |
| ITxM | 0.9 (0.6-1.3) | 0.93 (0.51-1.7) | 1.4 (0.62-3.1) | 0.87 (0.74-1.02) |
*
Data are reported as OR (95% CI). Reference group is 40-year-old male with 0 donations in last 24 months, not taking supplemental iron, weight 180 pounds, at ARC blood center.
†
For the Asian population the age group of “18–19” was combined with “20–29”.