Skip to main content
. Author manuscript; available in PMC: 2020 Apr 17.
Published in final edited form as: ACS Chem Biol. 2019 Nov 21;15(1):74–82. doi: 10.1021/acschembio.9b00552

Figure 4. R151785 inhibits both influenza A and B viruses.

Figure 4.

(A) Antiviral activity of R151785 against representative influenza A and B viruses. The antiviral activity of R151785 was determined in plaque reduction assay. Monolayers of MDCK or AX4 cells were infected with indicated viruses and incubated with overlays containing a serial of concentrations of R151785, 1 μM of amantadine or 0.2 μM of oseltamivir carboxylate. (B and C) Antiviral activity of R151785 against influenza virus at low to high MOIs. MDCK cells were infected A/California/ 07/2009 (H1N1) (B) and A/Switzerland/9715293/2013 (H3N2) (C) at different MOIs. The MOI of virus and concentration of compound were shown. The images shown were representative results from two repeats.