Table 1.
EC50 values of R160792 and R151785 against influenza A or B virus.
| Influenza Strains | Drug sensitivity | EC50 (μM)a | SIb | ||
|---|---|---|---|---|---|
| R160792 | R151785 | R160792 | R151785 | ||
| A/Solomon Islands/03/2006 (H1N1) | Amantadine Sensitive Oseltamivir Sensitive | 2.89 ± 0.25 | 0.93 ± 0.11 | 45.7 | > 322.6 |
| A/WSN/1933 (H1N1) | Amantadine Resistant Oseltamivir Sensitive | 6.65 ± 0.48 | 4.66 ± 0.22 | 19.9 | > 64.4 |
| A/California/07/2009 (H1N1) | 2.45 ± 0.15 | 1.43 ± 0.18 | 53.9 | > 209.8 | |
| A/Switzerland/9715293/2013 (H3N2) | 3.09 ± 0.13 | 2.71 ± 0.32 | 42.8 | > 110.1 | |
| A/North Carolina/39/2009 (H1N1) | Amantadine Resistant Oseltamivir Resistant | 4.63 ± 0.53 | 1.59 ± 0.07 | 28.6 | > 188.7 |
| A/Washington/29/2009 (H1N1) | 5.34 ± 0.26 | 2.26 ± 0.37 | 24.8 | > 132.7 | |
| A/Texas/04/2009 (H1N1) | 7.54 ± 0.41 | 2.27 ± 0.32 | 17.5 | > 132.1 | |
| A/Denmark/528/2009 (H1N1) | 5.09 ± 0.81 | 1.75 ± 0.10 | 25.9 | > 171.4 | |
| B/Wisconsin/01/2010 (Yamagata) | Amantadine Resistant Oseltamivir Sensitive | 3.81 ± 0.33 | 3.68 ± 0.31 | 34.7 | > 81.5 |
| B/Brisbane/60/2008 (Victoria) | 2.91 ± 0.11 | 1.33 ± 0.07 | 45.4 | > 225.6 | |
a,
EC50 was determined in the plaque assay using MDCK or AX-4 cells. Plaque areas were quantified for calculation of EC50 using Image J and Prism 7;
b,
CC50 values of R160792 and R151785 were 132 ± 32 μM and > 300 μM, respectively, in MDCK cells. SI is selectivity index, which was calculated by CC50/EC50. Means and SD from two experiments in duplicate or triplicate were shown.