Fig. 2.

Relationship between serum CXCL10 and CXCL9 and longitudinal decline in lung function.

We defined lung function decline as a percent change in absolute forced vital capacity or diffusing capacity of 10% or 15%, respectively, over the study period (~5 years). Total time at risk was 291 person-years. We used Cox proportional hazards models adjusted for age, race, sex, prior smoking, and immunosuppression use and dichotomized subjects based on chemokine levels above or below median values to assess the predictive value of these chemokines for lung function decline. Abbreviations: HR = hazard ratio.