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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Osteoarthritis Cartilage. 2019 Sep 14;27(12):1822–1830. doi: 10.1016/j.joca.2019.07.018

Figure 7. Strain is amplified in the interstitial extracellular matrix, pericellular matrix, and cellular (Cells) regions in samples following rapid (80 %/sec) compared to slow (0.1 %/sec) strain rate loading.

Figure 7.

Pore pressure was also increased in ECM, PCM, and cells, however, patterns of pressure did not match cell viability. In contrast, maximum principal and shear strains were amplified at each level, and there was a qualitative similarity between computational outcomes and patterns of cell viability. With the exception of the pore pressure, stress values were less influenced by strain rate at each spatial scale. (* p<0.05; ** p<0.0001)