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| Agent | Route | Dose | Schedule |
|---|---|---|---|
| Daunorubicin | IV | 25 mg/m2 | Days 1, 8, 15, 22 |
| Vincristine | IV | 1.5 mg/m2 (maximum dose 2 mg) | Days 1, 8, 15, 22 |
| Peg-Asparaginase* | IM/IV | 2500 IU/m2 (SD) 250–1000 IU/m2 (RED) | Day 4 |
| Dexamethasone | PO/IV | 10 mg/m2 | Days 1–7, 15–21 |
| Cytarabine | IT | 70 mg | Day 1 |
| Methotrexate | IT | 15 mg | Days 8, 29 |
Premedicated with hydrocortisone, diphenhydramine, and acetaminophen
Abbreviations: RED = Reduced-dose group; SD = Standard dose group.
