Table 3:

Spearman correlation coefficients comparing cell-free DNA levels, clinical scores, and the S63 DFR transcriptomic metric.

	nuDNA 12 hours	nuDNA 1 day	nuDNA 4 days	nuDNA 7 days	mtDNA 12 hours	mtDNA 1 day	mtDNA 4 days	mtDNA 7 days	Max SOFA first 24 hours	APACHE II	IL-6 12 hours	S63 DFR 12 hours	S63 DFR 1 day
nuDNA 12 hours	1	0.5804	0.4146	0.4547	0.4752	0.3583	0.2481	0.2630	0.2262	0.2560	0.0179	0.0115	0.0696
p-value		<.0001	<.0001	<.0001	<.0001	0.0002	0.0229	0.0267	0.0170	0.0067	0.8524	0.9083	0.5030
nuDNA 1 day		1	0.5258	0.3246	0.2545	0.2931	0.1982	0.2078	0.2411	0.1611	−0.0237	−0.0305	0.2129
p-value			<.0001	0.0065	0.0098	0.0027	0.0742	0.0867	0.0141	0.1040	0.8119	0.7665	0.0405
nuDNA 4 days			1	0.6248	0.2720	0.3357	0.4097	0.3867	−0.0178	−0.0778	−0.0811	0.0064	0.1323
p-value				<.0001	0.0123	0.0020	<.0001	0.0013	0.8713	0.4789	0.4606	0.9548	0.2613
nuDNA 7 days				1	0.4405	0.3648	0.5587	0.6266	0.0785	−0.0583	−0.0061	0.1236	0.1808
p-value					0.0001	0.0021	<.0001	<.0001	0.5152	0.6290	0.9595	0.3115	0.1562
mtDNA 12 hours					1	0.7155	0.5989	0.4228	0.0280	0.0891	−0.1446	−0.2000	−0.1700
p-value						<.0001	<.0001	0.0002	0.7706	0.3527	0.1300	0.0429	0.0995
mtDNA 1 day						1	0.7064	0.5948	−0.1213	−0.0945	−0.1446	−0.1875	−0.1514
p-value							<.0001	<.0001	0.2224	0.3424	0.1449	0.0660	0.1474
mtDNA 4 days							1	0.6442	−0.1917	−0.1567	−0.2046	−0.2430	−0.3309
p-value								<.0001	0.0788	0.1521	0.0603	0.0288	0.0040
mtDNA 7 days								1	0.0105	−0.1707	−0.1437	−0.1805	−0.0718
p-value									0.9305	0.1546	0.2319	0.1377	0.5762
Max SOFA first 24 hours									1	0.6458	0.1958	0.1981	0.2265
p-value										<.0001	0.0385	0.0438	0.0273
APACHE II										1	0.1020	0.2824	0.1096
p-value											0.2846	0.0037	0.2903
IL-6 12 hours											1	0.6101	0.5600
p-value												<.0001	<.0001
S63 DFR 12 hours												1	0.6857
p-value													<.0001
S63 DFR 1 day													1
p-value