Table 3.
Hierarchical Linear Model for the Severity of Chemotherapy-Induced Nausea
| Nausea | Coefficient (SE) | |
|---|---|---|
| Unconditional Model | Final Model | |
| Fixed effects | ||
| Intercept | 2.697 (.083)+ | 2.697 (.072)+ |
| Piecewise 1 - linear rate of change | 0.685 (.117)+ | 0.682 (.116)+ |
| Piecewise 1 - quadratic rate of change | −0.489 (.055)+ | −0.487 (.054)+ |
| Piecewise 2 - linear rate of change | 0.910 (.081)+ | 0.902 (.079)+ |
| Piecewise 2 - quadratic rate of change | −0.312 (.026)+ | −0.308 (.025)+ |
| Time invariant covariates | ||
| Intercept | ||
| Age | −0.027 (.005)+ | |
| SCQ score | 0.054 (.021) | |
| Karnofsky Performance Status score | −0.027 (.006)+ | |
| Feeling bloated | 0.351 (.138) | |
| Vomiting | 1.531 (.192)+ | |
| Lack of appetite | 0.856 (.135)+ | |
| Difficulty swallowing | 0.425 (.187)* | |
| Mouth sores | 0.443 (.159)* | |
| Constipation | 0.523 (.131)+ | |
| CTX Emetogenicity | ||
| Moderately vs minimal/low emetogenic CTX | 0.448 (.189) | |
| Highly vs minimal/low emetogenic CTX | 1.042 (.235)+ | |
| Piecewise 1 - linear rate of change | ||
| CTX Emetogenicity | ||
| Moderately vs minimal/low emetogenic CTX | 1.051 (.304)* | |
| Highly vs minimal/low emetogenic CTX | 1.689 (.372)+ | |
| Piecewise 1 - quadratic rate of change | 1.689 (.372)+ | |
| CTX Emetogenicity | ||
| Moderately vs minimal/low emetogenic CTX | −0.540 (.142)+ | |
| Highly vs minimal/low emetogenic CTX | −0.888 (.175)+ | |
| Piecewise 2 - linear rate of change | ||
| Age | −0.021 (.006)+ | |
| Child care responsibilities | −0.380 (.169)* | |
| Mouth sores | −0.420 (.162)* | |
| CTX Emetogenicity | ||
| Moderately vs minimal/low emetogenic CTX | 0.471 (.208)* | |
| Highly vs minimal/low emetogenic CTX | 1.175 (.256)+ | |
| Piecewise 2 - quadratic rate of change | ||
| Age | 0.007 (.002)* | |
| Child care responsibilities | 0.096 (.058) | |
| Mouth sores | 0.118 (.055) | |
| CTX Emetogenicity | ||
| Moderately vs minimal/low emetogenic CTX | −0.173 (.067) | |
| Highly vs minimal/low emetogenic CTX | −0.380 (.082)+ | |
| Variance components | ||
| Intercept | 6.466+ | 4.323+ |
| Piecewise 1 - linear rate of change - slope | 2.726+ | 2.309+ |
| Piecewise 1 - quadratic rate of change - slope | 0.460* | 0.347 |
| Piecewise 2 - linear rate of change - slope | 1.907+ | 1.511+ |
| Piecewise 2 - quadratic rate of change - slope | 0.182+ | 0.144+ |
| Goodness-of-fit deviance (parameters estimated) | 28588.996 (21)** | 28131.581 (46) |
| Model comparison x2 (df) | 457.385 (25)** | |
*
p<.05
**
p<.001
+
p<.0001
Abbreviations: CTX = chemotherapy; df = degrees of freedom; SCQ = Self-administered Comorbidity Questionnaire; SE = standard error