Open Field (n=24 per group). (A) Move time in the open field presented as Mean + SEM (^ - HD > W, p<.01; @ - HD > LD, p<.01). Insert: Move time during treatment (week 11) and abstinence (week 18) presented as Mean + SEM (*p<.05). (B) Distance traveled in the open field presented as Mean + SEM (^ - HD > W, p<.01; @ - HD > LD, p<.01). Insert: Distance traveled during treatment (week 11) and abstinence (week 18) presented as Mean + SEM (*p<.05). (C) Center distance traveled in the open field presented as Mean + SEM (^ - HD > W, p<.01; @ - HD > LD, p<.05). Insert: Center distance traveled during treatment (week 11) and abstinence (week 18) presented as Mean + SEM (*p<.05).