Table 2.

Advanced Imaging Techniques in Chronic Pancreatitis (CP)

Clinical Question	Specific Question	Useful Imaging techniques
Diagnosis of Structural/Functional Changes	Parenchymal	• T1 signal changes • Extracellular volume fraction • Contrast enhanced CT • Diffusion weighted imaging • MR Elastography • Pancreatic fat fraction (by MRI) • Dual-energy CT • 3D volumetry using AI • EUS with elastrography
	Ductal	• MRCP (with/without Secretin)
	Functional	• Secretin-enhanced MRCP • Perfusion CT • Radiomics
Assist in Therapeutic Decision Making	Diagnose obstruction	• MRCP (with/without Secretin) • Dual-energy CT
	Detect fluid collections	• Dual-energy CT (including material density images and virtual unenhanced images)
	Identify vascular complications	• Dual-energy CT (including material density images and virtual unenhanced images)
Differentiate CP from Pancreatic Adenocarcinoma	Determine contrast enhancement pattern and/or metabolic activity	• Dual-energy CT • MRI/MRCP • Perfusion CT • PET-CT • PET-MRI • Radiomics