Table 2:

[¹⁸F] FDG-PET/CT characteristics and selected texture parameters differentiating lymph node characterization in patients with HIV infection (group 1 vs 2)

Texture Parameter	Benign Nodes (n = 9)		Malignant Nodes (n = 13)		P Valuea	Cutoff	AUCb (GLIMMROC)
	Mean	SD	Mean	SD
Node characteristics
Size (cm)	1.400	0.300	1.892	0.690	.024	<2.0	0.752
Volume (cm3)	0.547	0.363	2.535	2.218	.007	>0.76	0.889
SUVmax	5.111	1.610	8.562	3.886	.042	>5.5	0.803
Histogram
Mean	624.4	74.6	735.3	75.2	.017	>683.3	0.872
Median	774.0	217.9	1013.1	71.2	.018	>877.8	0.872
Second SD	93.76	28.70	59.85	19.19	.017	<76.3	0.872
Range	273.7	82.9	175.4	54.5	.017	<232.7	0.863
Geometric mean	199.6	44.7	272.8	63.8	.032	>237.3	0.829
SD 5	81.9	29.4	16.8	19.2	.018	<62.89	0.872
SD 9	99.7	49.3	19.5	17.3	.017	<63.16	0.889
GLCM
Contrast	113.1	20.2	84.1	16.9	.009	<97.7	0.889
Energy	0.036	0.019	0.081	0.047	.025	>0.047	0.812
Homogeneity	0.451	0.065	0.542	0.069	.020	>0.498	0.821
GLRL
SRE	0.177	0.007	0.157	0.009	<.001	<0.164	0.966c
LRE	0.197	0.010	0.173	0.012	.001	<0.186	0.957
GLN	0.183	0.009	0.160	0.011	.001	<0.172	0.949
RLN	0.196	0.010	0.173	0.012	.002	<0.184	0.932
LRHGE	224.6	51.8	300.0	68.7	.035	>261.8	0.863

Note:—GLIMMROC indicates generalized linear mixed model receiver operating characteristic.

^aIndicates a significant difference by the mixed linear regression model (Proc MIXED) to adjust the variance-covariance matrix among multiple values recorded for each patient (P < .05).

^bUsing the generalized linear mixed model (GLIMMROC).

^cThe highest AUC among 41 texture features.