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. 2020 Feb 12;11:74. doi: 10.3389/fphys.2020.00074

TABLE 3.

Obstetric and perinatal outcomes of the matched day 3, day 5, day 6, and day 7 vitrified-warmed embryo transfer groups.

Outcome Day 3 Day 5 Day 6 Day 7 P-valuea P-valueb P-valuec
Gestational age (weeks)
 <32 weeks 2 (0.7) 0 (0.0) 3 (1.1) 1 (1.1) 0.579 0.250 1
 32–36 weeks 9 (3.2) 19 (6.8) 15 (5.4) 6 (6.5) 0.220 0.905 0.697
 ≥37 weeks 268 (96.1) 260 (93.2) 261 (93.5) 86 (92.5) 0.170 0.814 0.720
Mode of delivery (%) 0.027 0.198 0.883
 Vaginal 94 (33.7) 79 (28.3) 58 (20.8) 20 (21.5)
 Cesarean section 185 (66.3) 200 (71.7) 221 (79.2) 73 (78.5)
Sex (%) 0.905 0.588 0.469
 Male 145 (52.0) 156 (55.9) 159 (57.0) 49 (52.7)
 Female 134 (48.0) 123 (44.1) 120 (43.0) 44 (47.3)
Birthweight (g) 3350 (3020, 3610) 3400 (3068, 3700) 3340 (3050, 3690) 3400 (3095, 3665) 0.249 0.945 0.441
Z-score 0.27 (−0.41, 0.94) 0.42 (−0.22, 1.21) 0.32 (−0.34, 1.11) 0.55 (−0.22, 1.30) 0.027 0.707 0.215
 <1500 g 2 (0.7) 1 (0.4) 3 (1.1) 0 (0.0) 0.562 0.750 0.576
 <2500 g 7 (2.5) 9 (3.2) 11 (3.9) 2 (2.2) 0.846 0.738 0.531
 2500–4500 g 271 (97.1) 266 (95.3) 265 (95.0) 88 (94.6) 0.325 0.783 0.892
 >4500 g 1 (0.4) 4 (1.4) 3 (1.1) 3 (3.2) 0.050 0.373 0.168
SGA (<10th percentile) 16 (5.7) 13 (4.7) 10 (3.6) 2 (2.2) 0.262 0.374 0.738
VSGA (<3th percentile) 5 (1.8) 4 (1.4) 3 (1.1) 1 (1.1) 0.635 0.795 0.739
LGA (>90th percentile) 48 (17.2) 64 (22.9) 53 (19.0) 22 (23.7) 0.168 0.887 0.332
VLGA (>97th percentile) 17 (6.1) 30 (10.8) 27 (9.7) 12 (12.9) 0.034 0.570 0.379
Pregnancy complication (%)
 GDM 35 (12.5) 28 (10.0) 39 (14.0) 10 (10.8) 0.646 0.843 0.426
 PIH 14 (5.0) 11 (3.9) 12 (4.3) 3 (3.2) 0.579 0.753 0.770
 PPROM 8 (2.9) 5 (1.8) 4 (1.4) 4 (4.3) 0.504 0.236 0.111
 Pre-eclampsia 7 (2.5) 6 (2.2) 3 (1.1) 1 (1.1) 0.685 0.685 0.586
 Placenta previa 2 (0.7) 5 (1.8) 6 (2.2) 3 (3.2) 0.102 0.418 0.696
 Placental abruption 2 (0.7) 2 (0.7) 1 (0.4) 1 (1.1) 0.738 0.738 0.438
 Postpartum hemorrhage 6 (2.2) 8 (2.9) 10 (3.6) 2 (2.2) 1 0.711 0.675

PIH, pregnancy-induced hypertension; PPROM, preterm premature rupture of membranes. aP-value for day 3 vs. day 7. bP-value for day 5 vs. day 7. cP-value for day 6 vs. day 7. Bold values indicate statistically significant results.