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. 2020 Feb 12;13:17. doi: 10.3389/fnmol.2020.00017

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Copyright © 2020 Zeng, Shi, Zhan, Liu, Cai, Zhong, Wang, Chen, Huang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Continuous intrathecal injection of SIRT1 antagonist EX-527 upregulated DRG IL-33 and ST2. (A,B) The expression of IL-33 and ST2 significantly upregulated on day 5 after continuous delivery EX-527 in naïve rats. n = 4/group, ***p < 0.001 compared with the sham group.