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. 2020 Feb 12;11:54. doi: 10.3389/fimmu.2020.00054

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Copyright © 2020 Bulati, Miceli, Gallo, Amico, Carcione, Pampalone and Conaldi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein–protein interaction network generated for shared miRNA target genes after miRNET analysis. Only genes targeted by at least two differentially expressed miRNAs are shown. Upper images show networks with all interactions between deregulated miRNAs and genes involved in (A) negative regulation of immune system process, (B) cytokine signaling in immune system, and (C) toll-like receptor signaling pathway. (D) Distribution of the top-ranked deregulated miRNAs in the three analyzed pathways. (E) Table summarizing both the top-ranked miRNAs and the top-ranked genes showed in the network analysis. (F) Distribution of the top-ranked target genes in the three analyzed pathways.