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. 2020 Feb 18;10:2843. doi: 10.1038/s41598-020-59724-7

Table 4.

Haptoglobin and amyloid values in dairy cows with S. aureus-induced mastitis and treated with an intramammary suspension of AT-MSCs.

Item Treat Days post-infection
1 2 3 41,2 52 6 101 15 P
Haptoglobin (µg/mL) NEG 4.3 ± 0.4a 10.6 ± 0.4b 8.4 ± 4.1b 7.3 ± 4.1b 32.4 ± 11.4c 22.3 ± 8.4c 10.1 ± 5b 8.1 ± 4b 0.02
ATB 6.4 ± 4.4a 13.1 ± 5.9b 12.4 ± 5.8b 9.8 ± 4.6b 27.1 ± 2.3c 9.8 ± 9.4b 11.1 ± 6.5b 10.4 ± 4.9b 0.04
MSC 4.6 ± 0.9a 13.3 ± 3.5b 10.9 ± 5.5b 10 ± 5.2b 24.2 ± 5.2c 11.5 ± 6.4b 6.7 ± 2.3a 12.1 ± 4.5b 0.02
Amyloid A NEG 3.3 ± 0.25 3.3 ± 0.25 2.7 ± 0.23 2.3 ± 0.47 2.5 ± 0.5 2.8 ± 0.47 3.6 ± 0.25 3.5 ± 0.29 0.19
ATB 3.4 ± 0.4 3.2 ± 0.4 2.8 ± 0.6 2.3 ± 0.5 2.4 ± 0.43 2.8 ± 0.49 3.3 ± 0.5 3.5 ± 0.54 0.21
MSC 3.6 ± 0.24 3.3 ± 0.42 2.8 ± 0.73 2.6 ± 0.6 3 ± 0.45 2.3 ± 0.51 1.9 ± 0 2 ± 0.24 0.32

aNEG and MSC groups were administered intramammarily on Days 4 and 10 with PBS and 2,5 × 107 AT-MSCs, respectively. bATB group was administered intramammarily on Days 4 and 5 with Pirlimycin. a,bIndicate significant (P < 0.05) difference among groups of cows. a-c Indicate significant (P < 0.05) difference between experimental days and treatments.