Table 4.
Haptoglobin and amyloid values in dairy cows with S. aureus-induced mastitis and treated with an intramammary suspension of AT-MSCs.
Item | Treat | Days post-infection | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 41,2 | 52 | 6 | 101 | 15 | P | ||
Haptoglobin (µg/mL) | NEG | 4.3 ± 0.4a | 10.6 ± 0.4b | 8.4 ± 4.1b | 7.3 ± 4.1b | 32.4 ± 11.4c | 22.3 ± 8.4c | 10.1 ± 5b | 8.1 ± 4b | 0.02 |
ATB | 6.4 ± 4.4a | 13.1 ± 5.9b | 12.4 ± 5.8b | 9.8 ± 4.6b | 27.1 ± 2.3c | 9.8 ± 9.4b | 11.1 ± 6.5b | 10.4 ± 4.9b | 0.04 | |
MSC | 4.6 ± 0.9a | 13.3 ± 3.5b | 10.9 ± 5.5b | 10 ± 5.2b | 24.2 ± 5.2c | 11.5 ± 6.4b | 6.7 ± 2.3a | 12.1 ± 4.5b | 0.02 | |
Amyloid A | NEG | 3.3 ± 0.25 | 3.3 ± 0.25 | 2.7 ± 0.23 | 2.3 ± 0.47 | 2.5 ± 0.5 | 2.8 ± 0.47 | 3.6 ± 0.25 | 3.5 ± 0.29 | 0.19 |
ATB | 3.4 ± 0.4 | 3.2 ± 0.4 | 2.8 ± 0.6 | 2.3 ± 0.5 | 2.4 ± 0.43 | 2.8 ± 0.49 | 3.3 ± 0.5 | 3.5 ± 0.54 | 0.21 | |
MSC | 3.6 ± 0.24 | 3.3 ± 0.42 | 2.8 ± 0.73 | 2.6 ± 0.6 | 3 ± 0.45 | 2.3 ± 0.51 | 1.9 ± 0 | 2 ± 0.24 | 0.32 |
aNEG and MSC groups were administered intramammarily on Days 4 and 10 with PBS and 2,5 × 107 AT-MSCs, respectively. bATB group was administered intramammarily on Days 4 and 5 with Pirlimycin. a,bIndicate significant (P < 0.05) difference among groups of cows. a-c Indicate significant (P < 0.05) difference between experimental days and treatments.