Table 2.

The SNP-based heritabilities (h²) of eight pain phenotypes from the UK Biobank cohort and their genetic correlations with depressive symptoms, major depression and neuroticism

	Heritability		Depressive symptoms		Major depressive disorder		Neuroticism
Pain phenotypes	h2 (SE)	P	rg	P	rg	P	rg	P
Headache	0.21 (0.015)	3.9 × 10−45	0.52 (0.036)	1.6 × 10−46	0.39 (0.057)	1.6 × 10−11	0.50 (0.028)	2.2 × 10−72
Facial pain	0.24 (0.12)	0.036	0.33 (0.091)	2 × 10−4	0.34 (0.137)	0.01	0.30 (0.068)	1.0 × 10−5
Neck or shoulder pain	0.11 (0.017)	4.3 × 10−11	0.55 (0.048)	3.4 × 10−30	0.40 (0.073)	5.8 × 10−8	0.44 (0.039)	5.3 × 10−7
Stomach or abdominal pain	0.14 (0.050)	0.004	0.67 (0.134)	5.7 × 10−7	0.53 (0.15)	5 × 10−4	0.70 (0.118)	2.4 × 10−9
Back pain	0.11 (0.020)	8.4 × 10−9	0.48 (0.063)	1.5 × 10−14	0.36 (0.086)	3 × 10−5	0.40 (0.054)	1.7 × 10−13
Hip pain	0.12 (0.041)	0.005	0.34 (0.16)	0.03	0.04 (0.167)	0.80	0.27 (0.128)	0.04
Knee pain	0.08 (0.029)	0.007	0.12 (0.083)	0.13	−0.07 (0.113)	0.53	0.18 (0.057)	0.002
Pain all over body	0.31 (0.072)	1.3 × 10−5	0.69 (0.063)	1.4 × 10−27	0.43 (0.095)	5.6 × 10−6	0.45 (0.054)	3.4 × 10−17

P values < 0.001 (0.05/24 + 28) were considered as significant for genetic correlations. Those significant rg values were in bold

SE standard error, rg genetic correlation