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. 2020 Feb 18;10:2813. doi: 10.1038/s41598-020-59690-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Heatmap representation of DNA Human Methyl-seq data between CRC and normal samples on whole genes. Each column represents one sample and each row represents CpGs methylation status in hyper- hypo Methylation DMRs identified by DMRFusion. (B) Pair-wise correlation coefficients matrix comparing DNA methylation between CRC and normal groups in hyper- hypo methylation.