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. 2019 Dec 17;122(4):517–527. doi: 10.1038/s41416-019-0681-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic of the mode of action of docetaxel and mebendazole on microtubule networks. Mebendazole binds to the colchicine- binding site, while docetaxel stabilises the microtubule structure by binding to its inner surface. b CP2 cells were treated with different drug combinations (MBZ = mebendazole) and the IncuCyte (Essen Bioscience) used to calculate the decrease in percentage cell survival (left panel). Percentage cell survival was normalised to docetaxel treatment. n = 3 (independent experiments), mean values ± SD are shown, analysed by two-way ANOVA with Sidak’s multiple comparisons test, ***p < 0.0001. (The effects of docetaxel alone are shown in the right panel.) c PC3 cells were treated with the indicated drugs and analysed for changes in growth inhibition by cell counting. n = 3 (independent experiments), mean values ± SD are shown, analysed by two-way ANOVA with Sidak’s multiple comparisons test, *p < 0.01. d PC3M and docetaxel-resistant PC3M cells (PC3M DocR) were seeded in normal media 24 h before being treated with the indicated drugs and analysed for changes in growth inhibition by cell counting. n = 3 (independent experiments), mean values ± SD are shown, analysed by two-way ANOVA with Sidak’s multiple comparisons test, *p < 0.05.