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. 2019 Oct 25;28(3):349–357. doi: 10.1038/s41431-019-0533-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Illustration of the non-linear estimation of LOY mosaicism by mLRRY calculated from SNP-array data by comparisons with LOY estimates generated from the same set of samples using independent technologies. a, b show the comparisons between mLRRY calculated from SNP-array data with the corresponding LOY estimates generated from the pairwise studied samples using whole genome sequencing (WGS) and droplet digital PCR (ddPCR), respectively. c displays a high concordance between estimates of LOY in samples pairwise studied with WGS and ddPCR. A linear regression line with Pearson’s coefficient of determination (R²) is shown for each comparison