Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 25;28(3):349–357. doi: 10.1038/s41431-019-0533-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Comparison of the performance of two formulas developed for prediction of percentage of LOY from mLRRY-values, i.e. Danielsson’s formula presented here and the recently published Veitia’s formula. In a, the estimates of mosaicism from each formula are compared in a range of theoretically possible mLRRY-values representing varying degree of LOY. The values of mLRRY plotted on the Y-axis were used to predict the percentages of LOY plotted on the X-axis. In male subjects without LOY, mLRRY-values are close to zero and lower values indicate increasing level of LOY mosaicism. The mLRRY calculated from female samples typically range −3 to −4. The horizontal grey line at 100% represents an extreme level of mosaicism (Y loss in all cells) and thus indicates a maximum theoretical limit of predicted LOY mosaicism in men. b shows a similar comparison using authentic data generated from 121 samples studied with both SNP-array and ddPCR. The Y-axis shows the predicted percentage of LOY from SNP-array data using each formula and the level of mosaicism measured by ddPCR in corresponding samples are plotted on the X-axis. Grey lines indicate theoretical upper limits of LOY estimations. To illustrate the overestimation of LOY mosaicism generated by the Veitia’s formula, a black line connects the predictions from each formula in the sample with the highest level of LOY mosaicism