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. 2020 Feb 18;10:2800. doi: 10.1038/s41598-020-59523-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ultrastructure analysis of exosomes in healthy, IPMN and PDAC serum by TEM. Exosomes were separated from serum samples using Exoquick^TC, and subsequently purified by gel exclusion chromatography mentioned in methods. The samples were prepared for TEM and negative staining (n = 3 each). Images were acquired using JEOL JEM 1400 at 120 kV on a Gatan Ultrascan 1000 CCD. Red arrows depict exosomes. (a) Exosome vesicles in serum samples (n = 3 each) from healthy, IPMN and PDAC were measured (twenty vesicles/sample) randomly for their size distribution, and the median values are depicted. Vesicle size were lower in PDAC compared to healthy serum samples (*p = 0.032) (b).