Table 6.

Symptoms reported by enrolled Associates by age (adult = age ≥ 18 years, child = age ≤ 18 years), among those with symptomatic infections (defined as the presence of any solicited symptom) in Ecuador.

	Ecuador
	Total—by age			Total—by serology*			Primary			Secondary
	Child	Adult	p-value	1o	2o	p-value	Child	Adult	p-value	Child	Adult	p-value
# Dengue illnesses**	27	67	NA	42	45	NA	13	29		8	37
Asymptomatic	34.2%	32.9%	0.889	42.9%	22.2%	0.040	53.8%	37.9%	0.501	25.0%	21.6%	1.000
Hospitalized	0%	0%	NA				0%	0%	NA	0%	0%	NA
Fever	22.9%	14.1%	0.282	9.8%	20.0%	0.235	8.3%	10.3%	1.000	25.0%	18.9%	0.651
Headache	33.3%	27.8%	0.660	19.5%	37.8%	0.095	16.7%	20.7%	1.000	25.0%	40.5%	0.690
Rhinorrhea	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cough	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Nausea/vomiting	13.2%	7.6%	0.333	4.8%	8.9%	0.677	0.0%	6.9%	1.000	0.0%	10.8%	1.000
Drowsiness	16.7%	21.5%	0.623	14.6%	26.7%	0.195	8.3%	17.2%	0.651	12.5%	29.7%	0.419
Muscle/joint pain	11.1%	34.2%	0.012	31.7%	33.3%	1.000	25.0%	34.5%	0.719	12.5%	37.8%	0.236
Abdominal pain	13.9%	22.8%	0.323	17.1%	26.7%	0.311	8.3%	20.7%	0.651	25.0%	27.0%	1.000
Rash	22.2%	7.6%	0.034	14.6%	13.3%	1.000	33.3%	6.9%	0.050	25.0%	10.8%	0.286
Diarrhea	2.8%	11.4%	0.168	4.9%	15.6%	0.161	0.0%	6.9%	1.000	0.0%	18.9%	0.321
Retroorbital pain	13.9%	26.6%	0.155	17.1%	35.6%	0.087	16.7%	17.2%	1.000	25.0%	37.8%	0.691
Bleeding	0.0%	1.3%	1.000	2.4%	0.0%	0.477	0.0%	3.4%	1.000	0.0%	0.0%	NA

^*Of those with valid serological results (i.e., either primary or secondary DENV infection).

^**Among all those with confirmed DENV infection (i.e., whether symptomatic or asymptomatic).

P-values < 0.05 indicate statistically significant comparisons, applying Mantel-Haenszel chi-squared testing.

NA indicates not applicable.