Table 1.

The advantages and disadvantages of the diabetes model in dogs.

Diabetes model in dogs	Advantages	Disadvantages
Naturally occurring DM	• The incident of naturally occurring DM is very low in other large animals such as pigs and non-human primates • Phenotypic similarity to human type I DM • Equal standard therapy and dietary management with human type I DM • Ease of monitoring	• Complexity of study design • Patient inclusion and exclusion criteria determination • Regulations
Induced DM	• Equal standard therapy and dietary management with human type I DM • Ease of monitoring	• Induced non-islet tissue damage • Poor models for long-term evaluation of the disease complication