Table 4.
Univariate analysis of the EFS in JMML when the patients divided into HSCT and no-HSCT group
| Variable | HSCT cases (N = 45) | no-HSCT cases (N = 48) | ||||||
|---|---|---|---|---|---|---|---|---|
| N/total | EFS (%) | HR (95% CI) | P | N/total = 48 | EFS (%) | HR (95% CI) | P | |
| Gender | ||||||||
| Female | 15/45 | 53.3 | 1 | 17/48 | 42.5 | 1 | ||
| Male | 30/45 | 54.3 | 0.84 (0.33–2.10) | 0.706 | 31/48 | 26.7 | 1.54 (0.68–3.51) | 0.287 |
| Age at diagnosis | ||||||||
| ≤ 24 months | 19/45 | 83.9 | 1 | 31/48 | 28.5 | 1 | ||
| > 24 months | 26/45 | 32.6 | 5.36 (1.56–18.39) | 0.008 | 17/48 | 38.8 | 0.85 (0.39–1.84) | 0.67 |
| Platelet count at diagnosis (× 103/μL) | ||||||||
| ≥ 40 | 30/45 | 52.2 | 1 | 29/47 | 37.6 | 1 | ||
| < 40 | 15/45 | 59.3 | 1.05 (0.40–2.73) | 0.926 | 18/47 | 30.9 | 1.47 (0.69–3.15) | 0.318 |
| Myeloid or erythroid precursors on PB smear | ||||||||
| No | 8/43 | 43.8 | 1 | 9/38 | 29.2 | 1 | ||
| Yes | 35/43 | 59.3 | 0.72 (0.23–2.16) | 0.548 | 29/38 | 33.9 | 1.44 (0.49–4.27) | 0.509 |
| Fetal hemoglobin at diagnosis | ||||||||
| ≤ 10% | 5/29 | 80.0 | 1 | 2/16 | 50 | 1 | ||
| > 10% | 24/29 | 52.6 | 2.88 (0.37–22.35) | 0.311 | 14/16 | 35.8 | 1.58 (0.19–12.97) | 0.672 |
| Monosomy 7 | ||||||||
| Negative | 24/33 | 54.2 | 1 | 23/26 | 33.2 | 1 | ||
| Positive | 9/33 | 88.9 | 0.22 (0.03–1.71) | 0.147 | 3/26 | 0 | 1.58 (0.46–5.48) | 0.469 |
| Karyotype | ||||||||
| Normal | 20/34 | 58.2 | 1 | 21/28 | 39.4 | 1 | ||
| Abnormal | 14/34 | 57.1 | 0.96 (0.33–2.77) | 0.938 | 7/28 | 0 | 1.70 (0.64–4.54) | 0.289 |
| NF1 status | ||||||||
| Mutation absent | 29/45 | 60.0 | 1 | 38/48 | 32.2 | 1 | ||
| Mutation present | 16/45 | 43.8 | 1.65 (0.69–3.40) | 0.264 | 10/48 | 43.8 | 0.73 (0.28–1.94) | 0.532 |
| PTPN11 status | ||||||||
| Mutation absent | 24/45 | 65.2 | 1 | 31/48 | 49.8 | 1 | ||
| Mutation present | 21/45 | 42.9 | 1.72 (0.70–4.22) | 0.233 | 17/48 | 6.4 | 3.70 (1.71–8.00) | 0.001 |
| Somatic alterations at diagnosis | ||||||||
| 0 or 1 | 27/45 | 69.2 | 1 | 34/48 | 43.4 | 1 | ||
| 2 or more | 18/45 | 33.3 | 2.57(1.05–6.29) | 0.039 | 14/48 | 14.3 | 2.07 (0.98–4.39) | 0.058 |
| Mutation subtype | ||||||||
| Only one non-PTPN11 mutation | 16/45 | 67.7 | 1 | 25/48 | 54.6 | 1 | ||
| Only one PTPN11 mutation | 11/45 | 72.7 | 0.68 (0.16–2.84) | 0.595 | 9/48 | 13.3 | 3.77 (1.36–10.44) | 0.011 |
| Combined mutations without PTPN11 | 8/45 | 62.5 | 1.01 (0.24–4.22) | 0.994 | 6/48 | 33.3 | 1.79 (0.55–5.82) | 0.336 |
| PTPN11 mutation with additional alterations | 10/45 | 10.0 | 3.60 (1.20–10.79) | 0.022 | 8/48 | 0 | 4.44 (1.68–11.78) | 0.003 |
P values < 0.05% are shown in italics