Table 1.

Summary of the studies investigating molecular variants in human trace amine-associated receptors

References	Gene	Study design	Disease/phenotype	Sample size	Population
Duan et al. (2004)	TAAR6	Association study	Schizophrenia	827 subjects, from 192 families	European & African American
Abou Jamra et al. (2005)	TAAR1 TAAR5 TAAR6	Association study	Bipolar disorder	118 parent–offspring triads	European, German descent
				263 cases; 430 healthy controls
Bly et al. (2005)	TAAR2	Gene sequencing	Schizophrenia	56 cases; 56 healthy controls	Caucasian
Ikeda et al. (2005)	TAAR6	Association study	Schizophrenia	405 cases; 401 healthy controls (first-set analysis)	Japanese
				503 cases; 440 healthy controls (second-set analysis)
Amann et al. (2006)	TAAR6	Association study	Schizophrenia	85 affected; 34 parent–offspring triads; 19 families with ≥ 2 affected offspring	Arab–Israeli
Duan et al. (2006)	TAAR6	Association study	Schizophrenia	235 parent–offspring triads	Chinese Han
Venken et al. (2006)	TAAR6	Association study	Bipolar disorder	182 cases; 364 healthy controls; 9 families	Swedisha
Ludewick et al. (2008)	TAAR6	Association study	Schizophrenia	79 sib-pair families; 125 parent–offspring triads	European—German, Hungarian—and Israel
Pae et al. (2008b)	TAAR6	Association study	Schizophrenia Bipolar disorder MDD	281 schizophrenia; 190 bipolar disorder; 187 MDD; 288 healthy controls	Korean
Pae et al. (2008a)	TAAR6	Association study	Schizophrenia, PANSS scores	240 cases	Korean
Sanders et al. (2008)	TAAR6	Association study	Schizophrenia and schizoaffective disorder	1870 cases; 2002 healthy controls	European
Vladimirov et al. (2007)	TAAR6 TAAR2 TAAR5	Association study	Schizophreniab	1408 subjects, from 265 families	Irish
Pae et al. (2009b)	TAAR6	Association study, epistasis with HSP-70	Schizophrenia	281 cases; 288 healthy controls	Korean
Pae et al. (2009a)	TAAR6	Association study, epistasis with HSP-70	Bipolar disorder; response to treatment	171 cases; 288 healthy controls	Korean
Vladimirov et al. (2009)	TAAR6	Association study	Schizophrenia or poor-outcome schizoaffective disorder	627 cases; 1021 healthy controls	Irish
Pae et al. (2010)	TAAR6	Association study	Response to antidepressant treatment; suicide	187 cases	Korean
Smith et al. (2012)	TAAR1	Association study	Fibromyalgia	496 cases; 348 healthy controls	Caucasian
Anttila et al. (2013)	TAAR6 TAAR7P	Genome-wide meta-analysis	Migraine	23 285 cases; 95 425 healthy controls (29 GWAS	European
Park et al. (2014)	TAAR6	GWAS	Change in  %ΔFEV1 following ICS treatment	189 cases	Korean
Chang et al. (2015)	TAAR6	Association study	Change in  %ΔFEV1 following ICS treatment	246 cases	Korean
John et al. (2017)	TAAR1	Exome sequencing	Schizophrenia	4 members from 1 family 475 + 310 cases; 410 healthy controls	North Indian (475) & American (310)
Jones et al. (2017)	TAAR1 TAAR2	GWAS	Self-reported mosquito bite size	84 724 subjects	European
Mühlhaus et al. (2017)	TAAR1	Gene sequencing	Overweight/Obesity and disturbed glucose homeostasis	314 cases; 2018 healthy controlsc	German
Shahin et al. (2018)	TAAR2	GWAS	Response to β‐blockers	699 subjects	Any
Szekely et al. (2018)	TAAR8 TAAR6	GWAS	Cerebellar growth	LONG cohort: 458 subjects (119 with ADHD); Generation R: 257 subjects	Mixedd

%ΔFEV1 percentage of forced expiratory volume in 1 s, GWAS genome-wide association study, HSP-70 heat shock protein 70, ICS inhaled corticosteroids, MDD major depressive disorder

^aThe sample originates from the genetically isolated region of Västerbotten in northern Sweden

^bCore schizophrenia, including schizophrenia, poor-outcome schizoaffective disorder and simple schizophrenia. No evidence of association for broader diagnostic categories: narrow psychosis spectrum, adding schizotypal personality disorder and all other nonaffective psychotic disorders; broad psychosis spectrum, adding mood-incongruent and mood-congruent psychotic affective illness, and paranoid, avoidant and schizoid personality disorders; very broad psychosis spectrum, including all psychosis spectrum disorders plus non-psychotic affective disorders, anxiety, alcoholism, etc

^cDiabetes-free subjects older than 60 years of age from the population-based Study of Health in Pomerania (SHIP and SHIP-TREND) cohorts

^dLONG cohort: 404 European Americans, 31 African Americans, 8 Asian Americans, 15 mixed ethnicity; Generation R: 177 White/Caucasian, 80 non-Caucasian (African, Asian, and Caribbean)