. 2019 Oct 23;40(2):239–255. doi: 10.1007/s10571-019-00743-y

Table 2.

Single-nucleotide polymorphisms (SNPs) and variants (SNVs) in the human trace amine-associated receptor gene family

DbSNP database ID	Gene	Location (AA change)	Disease/phenotype	Association	References
rs4305745 (G>A)	TAAR6	3′-UTR	Schizophrenia	p = 0.0014	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Duan et al. (2006)
				ns	Ludewick et al. (2008)
				ns	Vladimirov et al. (2007)
				ns	Vladimirov et al. (2009)
			PANSS scores	ns	Pae et al. (2008a)
			Response to antipsychotics	ns	Pae et al. (2009b)
			BD	ns	Venken et al. (2006)
			Schizophrenia; BD; MDD	ns	Pae et al. (2008b)
			Response to antidepressants; suicide	ns	Pae et al. (2010)
			BD; response to treatment	ns	Pae et al. (2009a)
rs6937506 (G>A)	TAAR6	3′-UTR	Schizophrenia	p = 0.0052, d.n.s. Bonferroni	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Amann et al. (2006)
				ns	Duan et al. (2006)
				ns	Ludewick et al. (2008)
				ns	Vladimirov et al. (2007)
			BD	ns	Venken et al. (2006)
			Schizophrenia; BD; MDD	ns	Pae et al. (2008b)
			Suicide	p = 0.002	Pae et al. (2010)
			Response to antipsychotics	p < 0.001; balance accuracy = 0.53 (weak)	Pae et al. (2009b)
			BD; response to treatment	ns	Pae et al. (2009a)
rs6903874 (T>C)	TAAR6	3′-UTR	Schizophrenia	p = 0.0026, d.n.s. Bonferroni	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Amann et al. (2006)
				ns	Duan et al. (2006)
				ns	Ludewick et al. (2008)
				p = 0.012	Pae et al. (2008b)
				ns	Vladimirov et al. (2007)
				ns	Vladimirov et al. (2009)
			PANSS scores	ns	Pae et al. (2008a)
			BD	ns	Venken et al. (2006)
				p = 0.005	Pae et al. (2008b)
			MDD, response to antidepressants	p = 0.006	Pae et al. (2010)
			Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
			Response to antipsychotics	p < 0.001; balance accuracy = 0.52–0.54 (weak)	Pae et al. (2009b)
			BD; response to treatment	ns	Pae et al. (2009a)
rs2840837 (A>G)	TAAR6	Intergenic	Schizophrenia	ns	Duan et al. (2004)
rs2840837 (A>G)	TAAR6	Intergenic	Schizophrenia	ns	Amann et al. (2006)
rs1361280 (A>G)	TAAR6	Intergenic	Schizophrenia	ns	Duan et al. (2004)
				ns	Amann et al. (2006)
				ns	Vladimirov et al. (2007)
rs4473885 (C>T)	TAAR6	5′-UTR	Schizophrenia	ns	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Amann et al. (2006)
rs4085406 (A>G)	TAAR6	5′-UTR	Schizophrenia	ns	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Amann et al. (2006)
rs6907909 (A>G)	TAAR6	5′-UTR	Schizophrenia	ns	Duan et al. (2004)
				p = 0.0354 (first-set analysis) ns (second-set analysis)	Ikeda et al. (2005)
				ns	Amann et al. (2006)
				ns	Ludewick et al. (2008)
rs8192624 (G>A)	TAAR6	Exon, missense	Schizophrenia	ns	Duan et al. (2004)
				p = 0.014 (family study) p = 0.024 (case–control)	Abou Jamra et al. (2005)
				ns	Amann et al. (2006)
				ns	Vladimirov et al. (2007)
				ns	Vladimirov et al. (2009)
			Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs8192625 (G>A)	TAAR6	Exon, missense	Schizophrenia	ns	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Amann et al. (2006)
				ns	Ludewick et al. (2008)
				ns	Sanders et al. (2008)
				ns	Vladimirov et al. (2007)
				ns	Vladimirov et al. (2009)
			PANSS scores	p = 0.04 (total score) p = 0.01 (positive score) p = 0.007 (difference from baseline)	Pae et al. (2008a)
			Response to antipsychotics	ns	Pae et al. (2009b)
			BD	ns	Abou Jamra et al. (2005)
				ns	Venken et al. (2006)
			BD; response to treatment	ns	Pae et al. (2009a)
			Schizophrenia; BD; MDD	ns	Pae et al. (2008b)
			Response to antidepressants; suicide	ns	Pae et al. (2010)
			Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs7772821 (T>G)	TAAR6	3′-UTR	Schizophrenia	ns	Duan et al. (2004)
				ns	Ikeda et al. (2005)
				ns	Amann et al. (2006)
				ns	Vladimirov et al. (2007)
				ns	Vladimirov et al. (2009)
			BD	ns	Abou Jamra et al. (2005)
			Change in %ΔFEV1 following ICS	p = 6.08 × 10⁻⁵, ns	Park et al. (2014)
			Change in %ΔFEV1 following ICS	p_corr = 0.002 (codominant model) p_corr = 0.03 (dominant model) p_corr = 0.01 (recessive model)	Chang et al. (2015)
rs7745308 (T>G)	TAAR6	3′-UTR	Schizophrenia	ns	Duan et al. (2004)
rs7745308 (T>G)	TAAR6	3′-UTR	Schizophrenia	ns	Amann et al. (2006)
rs6912930 (T>G)	TAAR6	3′-UTR	Schizophrenia	ns	Duan et al. (2004)
			Schizophrenia	ns	Amann et al. (2006)
			Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs7765655 (G>A)	TAAR6	Intergenic	Schizophrenia	ns	Duan et al. (2004)
				ns	Amann et al. (2006)
				ns	Vladimirov et al. (2007)
				ns	Vladimirov et al. (2009)
rs4129284 (C>T)	TAAR6	Intergenic	Schizophrenia	ns	Duan et al. (2004)
rs4129284 (C>T)	TAAR6	Intergenic	Schizophrenia	ns	Amann et al. (2006)
rs9321354 (A>C)	TAAR6	3′-UTR	Schizophrenia	ns	Duan et al. (2004)
rs9321354 (A>C)	TAAR6	3′-UTR	Schizophrenia	ns	Amann et al. (2006)
rs9373026 (C>G)	TAAR6	5′-UTR	Schizophrenia	ns	Ikeda et al. (2005)
rs9373026 (C>G)	TAAR6	5′-UTR	Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs7452939 (G>A)^a	TAAR6	3′-UTR	Schizophrenia	ns	Ikeda et al. (2005)
				p = 0.019, d.n.s. Bonferroni	Pae et al. (2008b)
				p < 0.001; balance accuracy = 0.57 (weak)	Pae et al. (2009b)
			PANSS scores	ns	Pae et al. (2008a)
			BD; response to treatment	ns	Pae et al. (2009a)
			Response to antidepressants; suicide	ns	Pae et al. (2010)
			Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs12189813 (G>C)	TAAR6	Intergenic	Schizophrenia	p = 0.02	Vladimirov et al. (2007)
rs12189813 (G>C)	TAAR6	Intergenic	Schizophrenia	ns	Vladimirov et al. (2009)
rs9389011 (T>C)	TAAR6	Intergenic	Schizophrenia	p = 0.03	Vladimirov et al. (2007)
rs9389011 (T>C)	TAAR6	Intergenic	Schizophrenia	ns	Vladimirov et al. (2009)
rs8192622 (C>T)	TAAR6		Schizophrenia	ns	Vladimirov et al.(2009)
rs3813354 (G>A)				ns	Vladimirov et al. (2007)
rs9389015 (C>T)				ns
rs9389020 (T>C)	TAAR6		Schizophrenia	ns	Vladimirov et al. (2007)
rs9389020 (T>C)	TAAR6		Schizophrenia	p = 0.0228	Vladimirov et al. (2009)
rs9493381 (G>T)	TAAR6	5′-UTR	Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs9493381 (G>T)	TAAR6	5′-UTR	Cerebellar growth	p = 1.27 × 10⁻⁶, ns	Szekely et al. (2018)
rs8192618 (G>A)	TAAR1	Exon, missense R23C)	Schizophrenia	NI—cases: 450/0/0^b US—cases: 296/4/0 controls: 401/0/0	John et al. (2017)
rs8192618 (G>A)	TAAR1	Exon, missense R23C)	Overweight/Obesity and disturbed glucose homeostasis	cases: 313/1/0^b controls: 2018/0/0	Muhlhaus et al. (2017)
rs8192620 (T>C)	TAAR1	Exon, synon (V288=)	BD	ns	Abou Jamra et al. (2005)
rs8192620 (T>C)	TAAR1	Exon, synon (V288=)	Schizophrenia	NI—cases: 277/162/21^b US—cases: 170/75/9 controls: 230/139/31	John et al. (2017)
rs8192619 (G>A)	TAAR1	Exon, synon (C265=)	Fibromyalgia	p = 1.11 × 10⁻⁵	Smith et al. (2012)
rs8192619 (G>A)	TAAR1	Exon, synon (C265=)	Schizophrenia	NI—cases: 394/66/0^b US—cases: 228/28/1 controls: 336/63/1	John et al. (2017)
ss28447860 (C>G)	TAAR6	Intergenic	Schizophrenia	ns	Duan et al. ((2004)
ss28447862 (T>C)				ns
ss28447876 (G>A)				ns
ss28447863 (A>G) ss28447865 (C>T)				ns
ss28447866 (G>A)				ns
ss28447871 (G>A)				ns
rs8192627 (A>C)	TAAR5	Exon, missense	BD	ns	Abou Jamra et al. (2005)
Not reported	TAAR2	Exon, missense (W123STOP)	Schizophrenia	ns	Bly (2005)
rs17078770 (–/A)	TAAR6	3′-UTR	Schizophrenia	ns	Ikeda et al. (2005)
rs2842899 (T>A)	TAAR6	Intergenic	Schizophrenia	ns	Vladimirov et al. (2007)
rs2153174 (G>T)				ns
rs1933988 (A>C)				ns
rs2255071 (C>T)				ns
rs7744878 (G>A)				ns
rs7759367 (G>A)				ns
rs17195227 (T>C)				ns
rs17061477 (A>C)				ns
rs4320395 (G>A)				ns
rs9402439 (C>G)				ns
Not shown	TAAR2	Not shown	Schizophrenia	ns	Vladimirov et al. (2007)
Not shown	TAAR5	Not shown	Schizophrenia	ns	Vladimirov et al. (2007)
rs9399032 (T>A)	TAAR6; TAAR7P	Intergenic	Migraine	p = 3.66 × 10⁻⁶, ns	Anttila et al. (2013)
rs11961899 (A>G)	TAAR6	5′-UTR	Change in %ΔFEV1 following ICS	ns	Chang et al. (2015)
rs9402427 (C>T)		5′-UTR		ns
rs9402428 (G>A)		5′-UTR		ns
rs9373024 (T>C)		5′-UTR		ns
rs9389007 (A>G)		5′-UTR		ns
rs11154685 (A>G)		3′-UTR		ns
rs17802869 (T>G)		3′-UTR		ns
rs367888752 (C>A)	TAAR1	Exon, missense (C182F)	Schizophrenia	Only present in affected individuals	John et al. (2017)
rs149785438 (G>C)		Exon, missense (S47C)
rs567495315 (G>T)		Exon, missense (F51L)
Chr6: 132966261 (G>C)^c		Exon, missense (Y294T)
Chr6: 132966259 (A>G)^c		Exon, missense (L295S)
rs182618382 (A>G)		Exon, synon (L253=)
Chr6: 132966818 (C>T)^c		Exon, missense (A109T)
Chr6: 132966394 (A>G)^c		Exon, missense (V250A)
rs558642256 (T>A)		Exon, missense (S28C)
rs73775159 (T>G)		Exon, synon (T37=)
rs377606507 (C>T)		Exon, synon (E86=)
rs77004036 (G>A)		Exon, synon (T102=)
rs73557824 (A>G)		Exon, missense (Y173H)
rs114701711 (A>G)		Exon, synon (L215=)
rs540278394 (C>T)		Exon, missense (S244 N)
rs6926857 (T>C)		Exon, missense (T252A)
rs8192621 (T>C)		Exon, missense (R312R)
rs184898731 (G>A)	TAAR1; TAAR2	Intergenic	Self-reported mosquito bite size	p = 8.64 × 10⁻⁶, ns	Jones et al. (2017)
rs140960896 (G>A) rs200795344 (T>A)	TAAR1	Exon, missense (S49L) Exon, missense (I171L)	Overweight/Obesity and disturbed glucose homeostasis	Cases: 313/1/0^b; controls: 2000/9/0^b Cases: 313/1/0^b; controls: not available	Muhlhaus et al. (2017)
rs9385619 (C>T)	TAAR2	5′-UTR	Response to β‐blockers	p = 8.23 × 10⁻⁶, ns	Shahin et al. (2018)

%ΔFEV1 percentage of forced expiratory volume in 1 s, BD bipolar disorder, d.n.s. did not survive, ICS inhaled corticosteroids, MDD major depressive disorder, NI North Indian, PANSS positive and negative syndrome scale, US American, UTR untranslated region

^ars7452939 has merged into rs4305746

^bWT/Hetero/variant homozygous genotypes

^cReference SNP cluster ID not available; reported as position in assembly GRCh37.p13