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. 2020 Feb 18;22(2):49. doi: 10.1208/s12248-019-0411-1

Table I.

Physicochemical Properties and Structure of the Compounds Used for the Solubility Experiments (ChemDraw Professional 15)

Drug Ionization Lipophilicity (log P)* Solubility**
Neutral Drugs graphic file with name 12248_2019_411_Figa_HTML.gif Neutral (pKa=9.38) (28) 0.20 (28) High (28)
graphic file with name 12248_2019_411_Figb_HTML.gif Neutral (pKa=15)a 2.45 (29) Low (30)
Weak acids graphic file with name 12248_2019_411_Figc_HTML.gif Weak acid (pKa=3.8) (31) 2.29 (31) Low (31)
graphic file with name 12248_2019_411_Figd_HTML.gif Weak acid (pKa=4.5) (32) 4.00 (33) Low (32)
Weak Bases graphic file with name 12248_2019_411_Fige_HTML.gif Weak base (pKa=2.8) (34) -1.43 (35) High (34)
graphic file with name 12248_2019_411_Figf_HTML.gif Weak base (pKa=6.2) (36) 2.74 (37) Low (38)
graphic file with name 12248_2019_411_Figg_HTML.gif Weak base (pKa=4.5) (39) 6.20 (39) Low (40)
Ampholytes graphic file with name 12248_2019_411_Figh_HTML.gif Ampholyte [Weak base: pKa1=1.7/Weak acid:. pKa2=5.6] (41) 0.89a Low (42)

*Experimental values, ** based on the compound’s BCS (Biopharmaceutical Classification System) classification (high: BCS Class I and III; low: BCS Class II and IV) (27), aSource: DrugBank